Buchu - Nature's Wonder Pain Reliever and Anti-Inflammatory

Inflammation is essentially a protective response intended to eliminate the initial cause of cell injury (microbes, toxins).  The inflammatory response dilutes, neutralizes and removes the insulting agent and sets into motion, the process of tissue repair.  This process can be categorized as either acute or chronic depending on the time frame and the immune cels involved.  Acute inflammation is relatively short in duration (minutes or days) and is characterised by the presence of fluid and predominantly neutrophils.  Chronic inflammation on the other hand is characterised by an accumulation of lymphocytes and monocytes and is associated with vascular proliferation and fibrosis (loss of mobility and deformed joints).

 

The function of neutrophils is a multi-step process.  Firstly, the cells have to migrate from the blood to the site where the insult has taken place.  This movement is guided by the activation of certain proteins in the blood and this leads to the increased expression of certain markers on the surfaces of the cells (receptors).  At the site, the cells then eat the organism and destroy it by releasing potent activated enzymes or radicals generated from oxygen.  If the particle is too big to ingest, then the process still takes place but the damaging enzymes are released to the outside.  Hence the tissue damage which ensues an infection.

 

During this process, other cells are recruited from the blood: these include monocytes and lymphocytes.  When they arrive on site, the monocytes are in turn activated to release their inflammatory factors in the hope of being able to be more efficient in the cleaning up process.  These factors have potent effects not only locally but also at distant sites in the body.  Such factors not only have the baility to enhance inflammation but they also induce other physiological effects such as the mobilisation of calcium from bone, abnormal antibody formation and release from the B cells, etc.  Hence, one the monocytes have been activated into action, the factors released from these cells have profound long-term effects should the cells not be regulated (we are then in the realm of chronic inflammation).

 

 

 

Experimental Procedures:

 

Blood from healthy individuals was obtained and various cellular functions were measured.  These functions were measured and compared to cell preparations not having received dilutions of the Buchu oil extract.  In this way, we could compare what the response would have been under normal culture conditions versus the responses when Buchu oil was present.

 

The assays conducted included:

  • The increased expression of the markers on the surfaces of neutrophils: these markers are increased at the cell membrane in order to allow these cells to stick more easily to the endothelium of the blood vessels and to migrate through the tissues.  These markers are called the CD18/CD11b dimer.

 

  • The ability of both neutrophils and monocytes to synthesize and release of oxygen radicals (so-called oxidative burst) in the presence of a bacterium.  This response would be a normal physiological immunological response during an infection and is the process that is inhibited by using anti-inflammatory drugs to prevent tissue damage.

 

  • The production of IL6: this is the factor which is released by monocytes (especially during chronic inflammation) and it is responsible for the wide ranging physiological effects on bone, pain, abnormal antibody prodcution, etc.  

 

 

 

Summary of Results:

 

  • Buchu oil is a POTENT INHIBITOR of the oxidative burst, inhibiting this response by 67% at a 1:400 dilution.  As the oil is diluted out, so the inhibition decreases but is still present at 24% at a 1:3200 dilution.
  • Buchu oil extract has NO significant inhibitory effects on the expression of CD11b/CD18 at the surface of neutrophils and monocytes.  This implies that the cells can still become “sticky” and migrate through the blood vessel wall to the site where they are required.
  • Buchu oil INHIBITS the release of Il6 from monocytes when these cells are stimulated by stimuli in nature.
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Implications of findings and clinical applications:

 

  • Reduction of chronic pain
  • Reduction of inflammation, both acute and chronic
  • Use in arthritis, rheumatism and any other joint destroying process
  • Use in cases of cystitis, prostatitis, pyelonephritis, etc
  • Use by gout sufferers
  • Control of hypertension and water retention in susceptible individuals
  • Prevention of swelling and bruising following trauma of soft tissues

 

 

 

In summary, Buchu oil is a potent, natural anti-inflammatory

 

FORMULATED BUCHULIFE OIL DILUTIONS

  • Formulated BuchuLife OIL is diluted 1 in 400 in Salmon Oil, hence giving us a V/V concentration of 0.25% (total Formulated BuchuLife OIL in

each capsule)

  • Within the Formulated BuchuLife OIL, only 4% is Pulegone per capsule.
  • That works out at 0.25 X 0.04 = 0.01%, equivalent to 10mg of Pulegone per 100g capsule.
  • From the World Health Organisation document of Toxicity of Pulegone it is published that Pulegone tested in both acute and chronic studies for the safety as food additives was considered safe at even concentrations up to 250mg/kg body weight in these animal studies.
  • Humans taking the capsules certainly do not ingest this amount of pure Pulegone.
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